In hepatic tissue, hepatocytes and other liver cells incessantly secrete Extracellular Vesicles (EVs), which are nanoscale lipid bilayer-encapsulated particles. These EVs are molecularly rich, laden with bioactive material (-omics) that reflect the metabolic and pathological state of their cells of origin. A subset of these EVs migrates through the extracellular matrix—a complex scaffold of proteins and glycoproteins—ultimately entering systemic circulation. This translocation facilitates the dissemination of critical biological information, mediating intercellular, tissue-level, and systemic communication networks.
A blood draw contains billions of EVs, with the vast majority deriving from hematopoietic cell lines. However, within this multitude, a smaller yet diagnostically significant contingent originates from the liver. These hepatic EVs carry distinctive molecular patterns that can provide valuable insights into the physiological or pathological processes occurring within the liver, highlighting their potential as minimally invasive biomarkers for liver function and disease. This biology is also applicable for any other cell type and/or organ.
Mursla Bio has unlocked a new avenue for liquid biopsy biomarker discovery.
This is made possible with the integration of a suite of proprietary and patented innovations:
Mursla Bio has built compatible and scalable assays to bring the newly discovered biomarkers to clinics.
This is made possible with the integration of a suite of proprietary and patented innovations:
Targeted capture of hepatocyte-derived extracellular vesicles from plasma and subsequent multi-omic analysis reveals potential diagnostic markers of hepatocellular carcinoma
Ricardo Figueiras, Susana Vagueiro, Gillian Reynolds, Elnaz Persia, Raissa Kay, Tomás Dias.
2023 International Society for Extracellular Vesicles, poster number: PF09.09 (2023)
High-yield immunomagnetic isolation of EV sub-populations for downstream applications
Susana Vagueiro, Ricardo Figueiras, Elnaz Persia, Tomás Dias.
2023 International Society for Extracellular Vesicles oral presentation: LB3.7 (2023)
An electro-optical bead-nanochip technology for the ultrasensitive and multi-dimensional detection of small extracellular vesicles and their markers.
Tomás Dias, Ricardo Figueiras, Susana Vagueiro, Renato Domingues, Yu-Hsien Hung, Elnaz Persia, Pierre Arsène bioRxiv 2022.04.11.487936 (2022)
Tetraspanins distinguish separate extracellular vesicle subpopulations in human serum and plasma – Contributions of platelet extracellular vesicles in plasma samples
Nasibeh Karimi, Razieh Dalirfardouei, Tomás Dias, Jan Lötvall, Cecilia Lässer. Journal of Extracellular Vesicles, e12213 (2022)
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