Decoding cellular messengers 
to ENABLE curative treatments

First-in-class liver EV tests

who are the patients?

High-risk population for liver cancer

Nearly 10 million people in the United States and Europe are at high risk of developing liver cancer. This growing number of individuals is primarily comprised of patients with cirrhosis (scarring of the liver), which has various causes, such as obesity leading to metabolic dysfunction-associated steatohepatitis (MASH), viral hepatitis (B and C), and excessive alcohol consumption.

Early detection of liver cancer enables access to curative treatments such as ablation, resection, and transplants. Clinical best practice is for high risk patients to undergo biannual screening using ultrasound; however, the results are often insufficiently sensitive to detect early-stage cancers.

Mursla Bio is conducting a clinical study involving approximately 500 patients to validate a novel in vitro diagnostic (IVD) test to meet this clinical need.

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WHAT DO WE ANALYSE?

Liver-derived EVs in blood

Cells within organs, including the liver, continually shed tiny particles known as Extracellular Vesicles (EVs). These EVs are packed with various biological materials such as DNA, RNA, proteins, lipids, and metabolites, offering a real-time glimpse into the health of the originating cell.

Some of these EVs manage to navigate through the extracellular matrix—the complex network of proteins and sugars outside cells—and enter the bloodstream. Once in the circulation, they carry essential information from cell to cell, as well as between different tissues and organs.

When a blood sample is taken, it contains billions of these EVs, and although the large majority of them are released from blood cells, hundreds of thousands are derived from solid organs like the liver.

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HOW DO WE ANALYSE?

Novel liver-EV liquid biopsy platform

Mursla Bio's cutting-edge technology isolates and analyses rare, tissue-specific EVs in blood, such as those originating from the liver, with unmatched precision. This enables non-invasive tissue biopsy of a patient at any time, detecting molecular disease patterns, like cancer, at onset or recurrence. 

Furthermore, our approach extends across multiple 'omics' such as RNA and protein, surpassing the less deterministic DNA that has driven the first generation of cancer liquid biopsy tests.

This breakthrough is made possible by our innovative biomarker discovery platform, coupled with scalable assays that enable the clinical application of newly identified biomarkers. It features a suite of proprietary and patented innovations. 

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OUR news

Mursla Bio helps shape the standardisation of EV-based liquid biopsy for clinical use

Mursla Bio participates in a unique global initiative to standardise the clinical use of novel EV-based biomarkers for liquid biopsy

Mursla Bio to present at Bio-International 2023

Mursla Bio was selected to present at the largest pharmaceutical and biotech partnering event

Mursla Bio invited to Health Tech Showcase at London Stock Exchange

Showcase spotlights Mursla Bio's first-in-class science and upcoming milestones for flagship product launch

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